The first and most common symptom you need to watch for is jaundice, which is when your skin and eyes turn yellow. Jaundice is caused by a buildup of bilirubin, which is a natural chemical created in the liver. Usually, the liver eliminates bilirubin in bile, but if the bile duct is blocked by a tumor, it has nowhere to go. When this occurs, it usually means that the cancer has started in the head of the pancreas. As it spreads, it can affect the liver, which can cause jaundice.