After a while, liver disease can turn into liver failure. At this stage, one may have chronic fatigue, muscle weakness, memory loss, and confusion. They could even slip into a coma. Researchers say that persistent exhaustion and fatigue may be a symptom of liver damage. However, they still don’t know what causes a liver disease patient to be so exhausted, but they think it may be related to the changes in brain chemistry and hormone levels or even the high amount of toxins in the bloodstream. Regardless, it majorly affects a patient’s everyday life.